Blood Of Children Sampling
Should parents pay a blood bank to store
the blood from their newborn baby's
umbilical cord and placenta, in case that
child or another family member ever
needs it to treat cancer or leukemia?
Expectant parents are being urged to do so
by companies that have sprung up
during the past few years to sell cord-blood
banking as a form of "biological
insurance" against such dreaded
diseases. The pitch is based on reports in
medical journals, such as a major
study published last week in the New
England Journal of Medicine, showing that
cord blood can sometimes be used in
place of a bone marrow transplant. Like bone
marrow, cord blood is rich in
stem cells, which can churn out many different
types of cells to rebuild a
patient's blood supply and immune system after high
doses of radiation and
chemotherapy. And a patient's own cord blood, or that
from a relative, is
more likely than cord blood from an unrelated donor to be a
good tissue match
and to be accepted by the recipient's body. Some experts in
bone-marrow
transplantation and blood banking frown on the cord-blood business,
arguing
that people are being frightened into wasting money on a service they
will
probably never need. Moreover, private companies are growing in tandem
with
public banks, and some scientists worry that private banking will limit
public
access to cord blood. They are concerned because the cord blood in
private banks
remains the property of the donor family and is not available
to patients
seeking a compatible donor. But the companies say that however
remote the
possibility that the blood will be needed, people who choose to
bank their own
cord blood have a right to do so. In most cases their cord
blood would be thrown
away in the delivery room if they did not pay to bank
it. There are only a few
cord-blood banks in the United States, and most
hospitals do not have specially
trained staff members to collect the blood.
Like bone marrow, cord blood must be
matched to the recipient by tests for
six inherited traits that determine an
individual's tissue type. Cord blood
does not have to be as precisely matched as
bone marrow, but still, the
closer the match, the better the odds of success.
The weaker the match,
the more likely it is that the recipient's body will
reject the transplant,
or the transplant will attack the recipient's tissues, in
a life-threatening
reaction called graft versus host disease. The companies that
freeze cord
blood and bank it point out that a person's own cord blood is a
perfect
match, and a sibling's cord blood a more likely match than a specimen
from a
stranger. And so, the argument goes, the best way to protect an entire
family
from the unthinkable is to save the newborns' cord blood.
Promotional
literature for one company, Cord Blood Registry, in San Bruno,
Calif.,
emphasizes that people with cancer in the family may have a special
interest in
cord-blood banking, along with those who have the hardest time
finding matches,
which includes members of racial minorities, especially
families in which the
parents are of different races. According to a
spokeswoman, Scoti Kaesshaefer,
the company reaches parents-to-be by
promoting itself to doctors, nurses and
childbirth educators, and by leaving
information at hospitals. Among the
promotional materials the company
provided to the New York Times were copies of
articles from other newspapers
suggesting that cancer among children is on the
rise. The company also has a
Web site and an 800 number with a recorded greeting
that instructs callers to
have their credit cards ready. The idea of saving
one's own cord blood seems
to be catching on. Cord Blood Registry, which
describes itself as the largest
private cord-blood banking firm in the United
States, has stored 10,000
samples during the past three years: 1,500 in 1995,
3,000 in 1996 and
6,000 in 1997. The company charges an initial fee of $1,200 to
collect a
sample and freeze it, and then $95 a year to keep it stored in
liquid
nitrogen at the blood bank at the University of Arizona. Customers
include
people with perfectly healthy children, who just want extra peace of
mind, as
well as some families who have lost a child to leukemia or another
disease and
fear for the health of their other children. In its three years
of operation,
eight customers have retrieved their cord blood for use in
medical treatment,
said Kaesshaefer. All eight samples were used for siblings
or relatives, she
said. By contrast, the largest public-access bank of cord
blood, at the New York
Blood Center in Manhattan, has collected only
8,686 specimens in six years. But
nearly 800 of those samples have been used
to treat patients, many of them
children, in the United States and overseas.
Critics of private cord-blood
companies point out that even if a person with
banked cord blood does need a
transplant later, the stored blood may not be
the best choice. Dr. Pablo
Rubinstein, who directs the cord-blood program
at the New York Blood Center,
said there was a compelling medical argument
against using a patient's own cord
blood in some cases. In some young
children with leukemia, he said, malignant
cells were already present at
birth in the cord blood, and transfusing those
cells back into the child
later might contribute to a relapse. In addition, he
said, bone marrow from a
donor could help destroy diseased cells, an effect
known as graft versus
leukemia. A person's own cord blood might not have that
effect, and in some
cases even a sibling's might not. Dr. John Wagner, associate
director of bone
marrow transplantation at the University of Minnesota in
Minneapolis,
said that for a child being treated recently, he deliberately
rejected cord
blood from a sibling in favor of a well-matched unit from an
unrelated donor,
hoping to take advantage of its antileukemic effect. Dr.
Robertson
Parkman, director of bone marrow transplantation at Children's
Hospital
in Los Angeles, said he saw no point in banking cord blood for most
families.
"It's motivated by fear," he said. But in families with an
ill child who
might need a bone-marrow transplant, he said, it makes sense to
collect cord
blood from any siblings born later and save it. Medical centers
with
transplant programs will often perform that service, he said. So will some
of
the private companies, without a fee. When a bone-marrow donor could not
be
found for 4-year-old Joshua Kelton, who was suffering from leukemia,
his
parents, stationed at a military base in Honolulu, conceived another
child in
the hope that the baby's tissues would match Joshua's. They did, and
Cord Blood
Registry collected the cord blood at birth, stored it in
Arizona for a month,
and then, when Joshua was ready for the procedure,
transported it to a medical
center at Stanford University. Joshua was treated
with his infant brother's cord
blood in August, and has been declared free of
leukemia. "Right now, he's
100 percent," his father said in a telephone
interview, "a normal
child, the way he was before this happened." But the
Keltons' experience is
hardly representative. That the family was certain it
would need the cord blood
sets it apart from most families that store the
blood. Wagner is wary of the
hard sell of some of the cord-blood companies.
"My concern is that it be
presented fairly to expectant mothers, who are
already fairly vulnerable,"
he said. "I have a lot of obstetricians and
parents calling me and
complaining it's too late, they missed the
opportunity. Others call saying,
'Should I do this?' It's hard to answer.
I don't want to bias them. We have
someone now who takes the calls for me
because it got to be
overwhelming."